Levamlodipine

• Description:

  Levamlodipine ((S) -Amlodipine) is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina[1].

• Product Name Alternative:

  (S) -Amlodipine; Levoamlodipine

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H320

• Target:

  Calcium Channel; SOD

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Others; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/levamlodipine.html

• Purity:

  98.53

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (C1=C (COCCN) NC (C) =C (C (OC) =O) [C@@H]1C2=CC=CC=C2Cl) OCC

• Molecular Formula:

  C20H25ClN2O5

• Molecular Weight:

  408.88

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]Jain R, et al. Polyaniline-graphene oxide nanocomposite sensor for quantification of calcium channel blocker levamlodipine. Mater Sci Eng C Mater Biol Appl. 2016 Aug 1;65:205-14.|[2]Rong H, et al. [Effect of probucol on serum malondialdehyde and superoxide dismutase in patients with primary hypertension]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 May;37 (5) :458-62.|[3]Yang YL, et al. Synergic effects of levamlodipine and bisoprolol on blood pressure reduction and organ protection in spontaneously hypertensive rats. CNS Neurosci Ther. 2012 Jun;18 (6) :471-4.|[4]Lee YJ, et al. Amlodipine besylate and amlodipine camsylate prevent cortical neuronal cell death induced by oxidative stress. J Neurochem. 2011 Dec;119 (6) :1262-70.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Citation 01:

  Proc Natl Acad Sci U S A. 2025 May 6;122 (18) :e2425494122.|Cell. 2023 Nov 22;186 (24) :5363-5374.e16.

• CAS Number:

  103129-82-4