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Rapanone

CAT: 0804-HY-N8213-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N8213-01Size:5 mg
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Description
Rapanone is a natural benzoquinone. Rapanone exhibits a broad spectrum of biological actions, including anti-tumor, antioxidant, anti-inflammatory, antibacterial and antiparasitic. Rapanone also is a potent and selective human synovial PLA2 inhibitor, with an IC50 of 2.6 μM[1][2][3][4].
CAS Number
[573-40-0]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Bacterial; Parasite; Phospholipase
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rapanone.html
Concentration
10mM
Purity
99.20
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C(O)=C(CCCCCCCCCCCCC)C(C(O)=C1)=O
Molecular Formula
C19H30O4
Molecular Weight
322.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Andreu GLP, et, al. Rapanone, a naturally occurring benzoquinone, inhibits mitochondrial respiration and induces HepG2 cell death. Toxicol In Vitro. 2020 Mar;63:104737.|[2]Morais LS, et, al. Antileishmanial compounds from Connarus suberosus: Metabolomics, isolation and mechanism of action. PLoS One. 2020 Nov 6;15 (11) :e0241855.|[3]Vega-Hernández K, et, al. Discerning the antioxidant mechanism of rapanone: A naturally occurring benzoquinone with iron complexing and radical scavenging activities. J Inorg Biochem. 2017 May;170:134-147.|[4]Ospina LF, et, al. Inhibition of acute and chronic inflammatory responses by the hydroxybenzoquinonic derivative rapanone. Planta Med. 2001 Dec;67 (9) :791-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Phospholipase A

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