Nedocromil

• Description :

  Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2) .

• Product Name Alternative :

  FPL 59002

• UNSPSC :

  12352005

• Hazard Statement :

  H319

• Target :

  Histamine Receptor; Leukotriene Receptor; Prostaglandin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/Nedocromil.html

• Concentration :

  10mM

• Purity :

  98.75

• Solubility :

  DMSO : 16.67 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=CC(C2=CC3=C(N(CC)C(C(O)=O)=CC3=O)C(CCC)=C2O1)=O)O

• Molecular Formula :

  C19H17NO7

• Molecular Weight :

  371.34

• Precautions :

  H319

• References & Citations :

  [1]Wells E, et al. Characterization of primate bronchoalveolar mast cells. II. Inhibition of histamine, LTC4, and PGD2 release from primate bronchoalveolar mast cells and a comparison with rat peritoneal mastcells. J Immunol. 1986 Dec 15;137 (12) :3941-5.|[2]Myocardial remodeling in diabetic cardiomyopathy associated with cardiac mast cell activation. Huang ZG, et al. PLoS One. 2013;8 (3) :e60827.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  DP; LTC4/CysLT2

• CAS Number :

  [69049-73-6]