Products for Research Use Only
RegisterLogin

Forodesine

CAT: 0804-HY-16210-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-16210-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels[1][2].
CAS Number
209799-67-7
Product Name Alternative
BCX-1777; Immucillin-H
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Forodesine.html
Purity
99.10
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(NC=C2[C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O)=C2NC=N1
Molecular Formula
C11H14N4O4
Molecular Weight
266.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Bieghs L, et al. The effects of forodesine in murine and human multiple myeloma cells. Adv Hematol. 2010;2010:131895.|[2]Bantia S, et al. Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H) --a novel potent and orally active immunosuppressive agent. Int Immunopharmacol. 2001 Jun;1 (6) :1199-210.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Cell Metab. 2025 Jan 7;37 (1) :87-103.e10.|Chem Sci. 2024 Mar 4.|Int J Biol Sci. 2023 Jan 1;19 (3) :772-788.|J Med Chem. 2023 May 25;66 (10) :6652-6681.|Nat Commun. 2017 Aug 14;8 (1) :241. |Plant J. 2024 Mar;117 (5) :1432-1452.|SSRN. 2024 Mar 14.|Am J Physiol Cell Physiol. 2025 Nov 21.|bioRxiv. 2019 Oct. |Biosens Bioelectron. 2020 Dec 1;169:112616.|Cell Rep. 2020 May 12;31 (6) :107640.|Cell. 2019 Oct 31;179 (4) :864-879.e19.|J Biol Chem. 2022 May;298 (5) :101876.|Nat Metab. 2020 Jul;2 (7) :635-647.|Neurochem Res. 2024 Nov 16;50 (1) :13.|Nucleic Acids Res. 2020 Sep 25;48 (17) :e101.

Alternative Products

CatalogName
BA2862-50Forodesine
MBS3845346-01Forodesine hydrochloride
A20903-10Forodesine 10mg
A20903-5Forodesine 5mg
A20903-2Forodesine 2mg
A20903-1Forodesine 1mg
A20903-50Forodesine 50mg
A20903-25Forodesine 25mg
A20908-5Forodesine hydrochloride 5mg
A20908-50Forodesine hydrochloride 50mg

Popular Products