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Matuzumab

CAT: 0804-HY-P9969-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P9969-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Matuzumab (EMD 72000) is a humanized anti-EGFR monoclonal antibody that blocks EGFR activation and downstream signaling, inhibits tumor growth. Deglycosylation and the possible elimination of ADCC activity can reduce the in vivo anti-tumor activity of Mattuzumab[1].
CAS Number
339186-68-4
Product Name Alternative
EMD 72000
UNSPSC
12352203
Target
EGFR
Type
Inhibitory Antibodies
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/matuzumab.html
Purity
99.0
Solubility
H2O
Smiles
[Matuzumab]
Molecular Weight
(145.5 kDa)
References & Citations
[1]Joan H Schiller. Developments in epidermal growth factor receptor-targeting therapy for solid tumors: focus on matuzumab (EMD 72000) . Cancer Invest. 2008 Feb;26 (1) :81-95.|[2]Bier H, et al. Anti- (epidermal growth factor) receptor monoclonal antibodies for the induction of antibody-dependent cell-mediated cytotoxicity against squamous cell carcinoma lines of the head and neck. Cancer Immunol Immunother. 1998 May;46 (3) :167-73.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2

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