Blebbistatin

• Description:

  Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Myosin

• Type:

  Reference compound

• Related Pathways:

  Cytoskeleton

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/blebbistatin.html

• Purity:

  99.64

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  O=C1C2(O)C(N(C3=CC=CC=C3)CC2)=NC4=C1C=C(C)C=C4

• Molecular Formula:

  C18H16N2O2

• Molecular Weight:

  292.34

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Ho WT, et al. Targeting non-muscle myosin II promotes corneal endothelial migration through regulating lamellipodial dynamics. J Mol Med (Berl) . 2019 Sep;97 (9) :1345-1357.|[2]Liang Ma, et al. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015 Jan;25 (1) :24-38.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [674289-55-5]