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Centrinone

CAT: 0804-HY-18682-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-18682-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Centrinone (LCR-263) is a selective and reversible inhibitor of polo-like kinase 4 (PLK4) with a Ki of 0.16 nM.
CAS Number
[1798871-30-3]
Product Name Alternative
LCR-263
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Centrinone.html
Purity
98.28
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C([N+]([O-])=O)=CC=C1)=C1CS(C2=CC(F)=C(SC3=NC(NC4=NNC(C)=C4)=C(OC)C(N5CCOCC5)=N3)C=C2)(=O)=O
Molecular Formula
C26H25F2N7O6S2
Molecular Weight
633.65
Precautions
H302, H315, H319, H335
References & Citations
[1]Wong YL. et al. Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. 2015 Jun 5;348 (6239) :1155-60.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PLK4

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