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(R) -Leucic acid

CAT: 0804-HY-30216-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-30216-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -Leucic acid (D-α-Hydroxyisocaproic acid) is an orally active D-isomer of the α-hydroxy analogue of Leucine. (R) -Leucic acid is a metabolite of Lactobacillus and can promote intestinal fatty acid absorption by upregulating CD36 expression. (R) -Leucic acid can be used to study microbe-host interactions and the regulation of lipid metabolism by probiotics[1][2].
CAS Number
20312-37-2
Product Name Alternative
D-α-Hydroxyisocaproic acid
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Amino Acid Derivatives; Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/r-leucic-acid.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(O)[C@H](O)CC(C)C
Molecular Formula
C6H12O3
Molecular Weight
132.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Li Y, et al. Lactobacillus johnsonii-derived leucic acid promotes fatty acid absorption and deposition by targeting CD36. Sci China Life Sci. 2025 Jun;68 (6) :1727-1739. |[2]Boebel KP, Baker DH. Comparative utilization of the α-keto and D-and L-α-hydroxy analogs of leucine, isoleucine and valine by chicks and rats. The Journal of nutrition. 1982 Oct 1;112 (10) :1929-39.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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