Hemiasterlin

• Description :

  Hemiasterlin ((-) -Hemiasterlin) is an antimitotic marine natural product with potent anticancer effects. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) [1].

• Product Name Alternative :

  (-) -Hemiasterlin; Milnamide B

• UNSPSC :

  12352005

• Target :

  ADC Payload

• Type :

  Natural Products

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hemiasterlin.html

• Purity :

  99.90

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OC(/C(C)=C/[C@H](C(C)C)N(C)C([C@H](C(C)(C)C)NC([C@@H](NC)C(C)(C1=CN(C)C2=CC=CC=C12)C)=O)=O)=O

• Molecular Formula :

  C30H46N4O4

• Molecular Weight :

  526.71

• References & Citations :

  [1]Jiraborrirak Charoenpattarapreeda, et al. Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics. Angew Chem Int Ed Engl. 2020 Dec 14;59 (51) :23045-23050.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Pyrrolobenzodiazepines

• CAS Number :

  [157207-90-4]