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W6134

CAT: 0804-HY-163192-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-163192-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
W6134 is highly potent and selective RORγ covalent inhibitor with an IC50 of 0.21 μM. W6134 exhibits excellent selectivity for RORγ over RORα, RXRγ, and ERRγ. W6134 significantly inhibits RORγ transcriptional activity W6134 inhibits the proliferation and colony formation and induces apoptosis in castration-resistant prostate cancer cells (CRPC) . W6134 can be used for the research of castration-resistant prostate cancers (CRPC) [1].
CAS Number
2983540-55-0
UNSPSC
12352005
Target
Apoptosis; ROR
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/w6134.html
Purity
99.90
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C2=C(C=CC=C2)NC(C=C)=O)C(Cl)=C1)CC3=CC=C(C=C3)S(=O)(CC)=O
Molecular Formula
C25H23ClN2O4S
Molecular Weight
482.98
References & Citations
[1]Fang W, et al. Discovery of the First-in-Class RORγ Covalent Inhibitors for Treatment of Castration-Resistant Prostate Cancer. J Med Chem. 2024 Jan 16.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RORγ

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CatalogName
GTR19234813-01W6134

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