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Ruplizumab

CAT: 0804-HY-P99315-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99315-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ruplizumab (BG 9588) is a humanized anti-CD40L IgG1κ monoclonal antibody. By binding to CD40L, Ruplizumab blocks its interaction with the CD40 receptor, inhibits T-B cell costimulatory signals, and mediates the depletion of activated T cells via the Fc segment. Ruplizumab has immunosuppressive effects. Ruplizumab can be used in the study of systemic lupus erythematosus, organ transplant rejection, and autoimmune diseases. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control[2].
CAS Number
220651-94-5
Product Name Alternative
BG 9588; Anti-Human CD40L Recombinant Antibody; Hu5c8
UNSPSC
12352203
Target
TNF Receptor
Type
Inhibitory Antibodies
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ruplizumab.html
Purity
99.84
Solubility
10 mM in DMSO
Smiles
[Ruplizumab]
Molecular Weight
(145.68 kDa)
References & Citations
[1]Chris Chamberlain, et al. Repeated administration of dapirolizumab pegol in a randomised phase I study is well tolerated and accompanied by improvements in several composite measures of systemic lupus erythematosus disease activity and changes in whole blood transcriptomic profiles. Ann Rheum Dis. 2017 Nov;76 (11) :1837-1844.|[2]Law C L, et al. Therapeutic interventions targeting CD40L (CD154) and CD40: the opportunities and challenges. Therapeutic targets of the TNF superfamily, 2009: 8-36.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2

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