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KS100

CAT: 0804-HY-146682-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-146682-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KS100 is a potent ALDH inhibitor with IC50s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase[1].
CAS Number
2408477-54-1
UNSPSC
12352005
Target
Aldehyde Dehydrogenase (ALDH) ; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ks100.html
Purity
99.61
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
N=C(SCC1=CC=C(C=C1)CN2C(C(C3=CC(Br)=CC(Br)=C32)=O)=O)N.Br
Molecular Formula
C17H14Br3N3O2S
Molecular Weight
564.09
References & Citations
[1]Dinavahi SS, et al. Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents. Eur J Med Chem. 2020 Feb 1;187:111962.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALDH1; ALDH2; ALDH3

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