Isovaleric acid

Isovaleric acid

• CAS Number: 503-74-2
• UNSPSC Description: Isovaleric acid is an oral active short-chain fatty acid that inhibits osteoclast differentiation by stimulating AMPK phosphorylation and promotes colonic smooth muscle relaxation by activating the cAMP/PKA pathway. Isovaleric acid can be used in research on skeletal diseases (such as osteoporosis) and intestinal disorders[1][2][3][4].
• Target Antigen: AMPK; Endogenous Metabolite; PKA
• Type: Natural Products
• Related Pathways: Epigenetics;Metabolic Enzyme/Protease;PI3K/Akt/mTOR;Stem Cell/Wnt;TGF-beta/Smad
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/3-Methylbutanoic_acid.html
• Purity: 98.0
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
• Smiles: CC(C)CC(O)=O
• Molecular Weight: 102.13
• References & Citations: [1]Ackman RG, et al. Birthweights in the Faroe Islands: possible role of isovaleric acid. J Intern Med. 1989 Feb;225(2):73-5.|[2]Ribeiro C A J, et al. Isovaleric acid reduces Na+, K+-ATPase activity in synaptic membranes from cerebral cortex of young rats[J]. Cellular and molecular neurobiology, 2007, 27: 529-540.|[3]Cho K M, et al. Isovaleric acid ameliorates ovariectomy‐induced osteoporosis by inhibiting osteoclast differentiation[J]. Journal of Cellular and Molecular Medicine, 2021, 25(9): 4287-4297.|[4]Blakeney BA, et al. Branched Short-Chain Fatty Acid Isovaleric Acid Causes Colonic Smooth Muscle Relaxation via cAMP/PKA Pathway. Dig Dis Sci. 2019 May;64(5):1171-1181.
• Shipping Conditions: Room Temperature
• Storage Conditions: Store at room temperature 3 years
• Clinical Information: No Development Reported