Isovaleric acid

• Description:

  Isovaleric acid is an oral active short-chain fatty acid that inhibits osteoclast differentiation by stimulating AMPK phosphorylation and promotes colonic smooth muscle relaxation by activating the cAMP/PKA pathway. Isovaleric acid can be used in research on skeletal diseases (such as osteoporosis) and intestinal disorders[1][2][3][4].

• UNSPSC:

  12352211

• Hazard Statement:

  H227, H314, H402

• Target:

  AMPK; Endogenous Metabolite; PKA

• Type:

  Natural Products

• Related Pathways:

  Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/3-Methylbutanoic_acid.html

• Purity:

  99.98

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

• Smiles:

  CC(C)CC(O)=O

• Molecular Formula:

  C5H10O2

• Molecular Weight:

  102.13

• Precautions:

  H227, H314, H402

• References & Citations:

  [1]Ackman RG, et al. Birthweights in the Faroe Islands: possible role of isovaleric acid. J Intern Med. 1989 Feb;225 (2) :73-5.|[2]Ribeiro C A J, et al. Isovaleric acid reduces Na+, K+-ATPase activity in synaptic membranes from cerebral cortex of young rats[J]. Cellular and molecular neurobiology, 2007, 27: 529-540.|[3]Cho K M, et al. Isovaleric acid ameliorates ovariectomy‐induced osteoporosis by inhibiting osteoclast differentiation[J]. Journal of Cellular and Molecular Medicine, 2021, 25 (9) : 4287-4297.|[4]Blakeney BA, et al. Branched Short-Chain Fatty Acid Isovaleric Acid Causes Colonic Smooth Muscle Relaxation via cAMP/PKA Pathway. Dig Dis Sci. 2019 May;64 (5) :1171-1181.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite; Microbial Metabolite

• CAS Number:

  [503-74-2]