PS48

• Description :

  PS48 is an activator of PDK1 with an AC50 of 8 μM.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  PDK-1

• Type :

  Reference compound

• Related Pathways :

  PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/PS48.html

• Purity :

  99.71

• Solubility :

  H2O : < 0.1 mg/mL (ultrasonic)

• Smiles :

  O=C(O)/C=C(C1=CC=CC=C1)/CCC2=CC=C(Cl)C=C2

• Molecular Formula :

  C17H15ClO2

• Molecular Weight :

  286.75

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Hindie V, et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol. 2009 Oct;5 (10) :758-64.|[2]Han F, et al. Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway. Int J Biol Sci. 2017 Sep 21;13 (10) :1266-1275.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1180676-32-7]