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PS48

CAT: 0804-HY-15967-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15967-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PS48 is an activator of PDK1 with an AC50 of 8 μM.
CAS Number
[1180676-32-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PDK-1
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PS48.html
Purity
99.71
Solubility
H2O : < 0.1 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C(C1=CC=CC=C1)/CCC2=CC=C(Cl)C=C2
Molecular Formula
C17H15ClO2
Molecular Weight
286.75
Precautions
H302, H315, H319, H335
References & Citations
[1]Hindie V, et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol. 2009 Oct;5 (10) :758-64.|[2]Han F, et al. Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway. Int J Biol Sci. 2017 Sep 21;13 (10) :1266-1275.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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