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APHS

CAT: 0804-HY-129284-01Size: 1 mg (38.11 mM x 100 μL in Methyl Acetate)Dry Ice: NoHazardous: No
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CAT#:0804-HY-129284-01Size:1 mg (38.11 mM x 100 μL in Methyl Acetate)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
APHS is a specific and covalent COX-2 inhibitor with neuroprotective effects. COX-2 is a prostaglandin (PG) synthetase overexpressed in colorectal cancer (CRC) and has pleiotropic cancer-promoting effects. APHS modifies COX-2 by acetylating the active site (serine 516), thereby inhibiting prostaglandin production. The neuroprotective activity of APHS is inhibited by prostaglandin E2. APHS also co-inhibits the WNT pathway, an anti-tumor mechanism in addition to COX-2 inhibition[1][2].
CAS Number
209125-28-0
UNSPSC
12352005
Hazard Statement
H225-H319-H336
Target
COX; Wnt
Type
Reference compound
Related Pathways
Immunology/Inflammation; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aphs.html
Concentration
38.11 mM * 100 μL in Methyl acetate
Purity
99.0
Solubility
10 mM in DMSO
Smiles
CCCCC#CCSC1=CC=CC=C1OC(C)=O
Molecular Formula
C15H18O2S
Molecular Weight
262.37
Precautions
P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P370+P378-P403+P233-P403+P235-P405-P501
References & Citations
[1]Carlson NG. Neuroprotection of cultured cortical neurons mediated by the cyclooxygenase-2 inhibitor APHS can be reversed by a prostanoid. J Neurosci Res. 2003 Jan 1;71 (1) :79-88.|[2]Humar B, McNoe L, Dunbier A, Heathcott R, Braithwaite AW, Reeve AE. Heterogeneous gene expression changes in colorectal cancer cells share the WNT pathway in response to growth suppression by APHS-mediated COX-2 inhibition. Biologics. 2008 Jun;2 (2) :329-37.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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