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ARN25068

CAT: 0804-HY-144290-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-144290-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation[1].
CAS Number
2649882-80-2
UNSPSC
12352005
Target
DYRK; GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/arn25068.html
Purity
99.66
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
C1(CNC2=NC(NC3=CC(C4CC4)=NN3)=C5SC=CC5=N2)=CC=CC=C1
Molecular Formula
C19H18N6S
Molecular Weight
362.45
References & Citations
[1]Stefania Demuro, et al. ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. Eur J Med Chem. 2022 Feb 5;229:114054.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DYRK1

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