Ergothioneine

CAT: 0804-HY-N1914-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
CAT#:0804-HY-N1914-01Size:10 mM - 1 mL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ergothioneine is an imidazole-2-thione derivative with orally active histidine betaine. Ergothioneine is a specific inhibitor of p38-MAPK and Akt, which plays a protective role in cell apoptosis induced by stress. Ergothioneine has antioxidant activity[1][2].
CAS Number
[497-30-3]
Product Name Alternative
L- (+) -Ergothioneine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Akt; Endogenous Metabolite; Keap1-Nrf2; NF-κB; p38 MAPK
Type
Natural Products
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ergothioneine.html
Purity
99.98
Solubility
H2O : 125 mg/mL (ultrasonic)
Smiles
S=C1NC(C[C@@H](C([O-])=O)[N+](C)(C)C)=CN1
Molecular Formula
C9H15N3O2S
Molecular Weight
229.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Colognato R, et al. Modulation of hydrogen peroxide-induced DNA damage, MAPKs activation and cell death in PC12 by ergothioneine. Clin Nutr. 2006 Feb;25 (1) :135-45.|[2]Salama SA, et al. Ergothioneine mitigates cisplatin-evoked nephrotoxicity via targeting Nrf2, NF-κB, and apoptotic signaling and inhibiting γ-glutamyl transpeptidase. Life Sci. 2021 Aug 1;278:119572.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
Phase 3
Isoform
Human Endogenous Metabolite; Microbial Metabolite

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