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GS87

CAT: 0804-HY-134557-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134557-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GS87 is a highly specific and potent GSK3 inhibitor with IC50s of 415nM and 521nM for GSK3α and GSK3β, respectively. GS87 induces differentiation of acute myeloid leukemia (AML) cell lines by effectively activating GSK3-dependent signaling components including MAPK signaling. GS87 modulates key GSK3 target proteins involved in cell proliferation and differentiation more effectively than Lithium and SB415285 (SB) . GS87 has the potential for acting as a differentiation agent for non-promyelocytic AML research[1].
CAS Number
919936-70-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gs87.html
Purity
99.81
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C1(C2=NN=C(SCC3=NC(C4=CC=CC=C4)=NO3)O2)=CC=NC=C1
Molecular Formula
C16H11N5O2S
Molecular Weight
337.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Sophia Hu, et al. A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity. Mol Cancer Ther. 2016 Jul;15 (7) :1485-1494.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3α; GSK-3β

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CatalogName
T8605-01GS87

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