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2-Hydroxycinnamaldehyde

CAT: 0804-HY-N3149A-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N3149A-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits Wnt/β-catenin, STAT3 signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities[1][2][3].
CAS Number
3541-42-2
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Apoptosis; STAT; Wnt; β-catenin
Type
Natural Products
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2-hydroxycinnamaldehyde.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=CC=CC1=C(O)C=CC=C1
Molecular Formula
C9H8O2
Molecular Weight
148.16
Precautions
H315, H319
References & Citations
[1]Lee MA, et al. Antitumor activity of 2-hydroxycinnamaldehyde for human colon cancer cells through suppression of β-catenin signaling. J Nat Prod. 2013 Jul 26;76 (7) :1278-84.|[2]Yoon YJ, et al. 2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2. Cancer Lett. 2018 Oct 10;434:42-55.|[3]Hao Let al. 2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice. Exp Mol Med. 2021 May;53 (5) :875-884.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Chemical Information

2-Hydroxycinnamaldehyde

(E)-3-(2-Hydroxyphenyl)-2-propenal is a member of cinnamaldehydes.

CAS Number3541-42-2
PubChem CID5318169
IUPAC Name(E)-3-(2-hydroxyphenyl)prop-2-enal
Molecular FormulaC9H8O2
Molecular Weight148.16
XLogP1.5
Topological Polar Surface Area37.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count11
Formal Charge0
Complexity152
SMILES
C1=CC=C(C(=C1)/C=C/C=O)O
InChI
InChI=1S/C9H8O2/c10-7-3-5-8-4-1-2-6-9(8)11/h1-7,11H/b5-3+
InChIKey
BSDNZCQPDVTDET-HWKANZROSA-N
Chemical Structure
2D Structure
2D structure of 2-Hydroxycinnamaldehyde
CAS: 3541-42-2
CID: 5318169
Formula: C9H8O2
MW: 148.16
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight148.16
XLogP31.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass148.052429494
Monoisotopic Mass148.052429494
Topological Polar Surface Area37.3 Ų
Heavy Atom Count11
Formal Charge0
Complexity152
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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