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Isojacareubin

CAT: 0804-HY-N8306-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N8306-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isojacareubin can be isolated from Hypericum japonicum. Isojacareubin covalently inhibits SARS-CoV-2 3CLpro. Isojacareubin also has anti-helicobacter activity. Isojacareubin inhibits PKC, and suppresses hepatocellular carcinoma metastasis and induces apoptosis[1][2][3].
CAS Number
50597-93-8
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Bacterial; PKC; SARS-CoV
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Epigenetics; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/isojacareubin.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(OC3=C1C=CC(O)=C3O)C(C=CC(C)(C)O4)=C4C=C2O
Molecular Formula
C18H14O6
Molecular Weight
326.30
Precautions
H315, H319, H335
References & Citations
[1]Kyoko Ishiguro, et al. An isopentenylated flavonol from Hypericum japonicum. Phytochemistry. 1993. 32 (6), 1583-1585.|[2]Khan A, et al. Discovery of Isojacareubin as a covalent inhibitor of SARS-CoV-2 main protease using structural and experimental approaches. J Med Virol. 2023 Feb;95 (2) :e28542.|[3]Yuan X, et al. Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo. Sci Rep. 2015 Aug 6;5:12889.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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