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DN5355

CAT: 0804-HY-159083-04Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-159083-04Size:50 mg
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Description
DN5355 is a small molecule compound that targets amyloid β protein (Aβ) and hyperphosphorylated tau protein. DN5355 can inhibit the aggregation of Aβ and tau protein and disaggregate the formed Aβ and tau protein fibers. DN5355 can be used in the study of Alzheimer's disease[1].
CAS Number
937012-09-4
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dn5355.html
Purity
99.01
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NC(S/C1=C\C2=CNC3=C2C=CC=N3)=S
Molecular Formula
C11H7N3OS2
Molecular Weight
261.32
References & Citations
[1]Sohui Park, et al. Modulation of Amyloid and Tau Aggregation to Alleviate Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease. ACS Pharmacology & Translational Science (2024) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

4-hydroxy-5-[(Z)-pyrrolo[2,3-b]pyridin-3-ylidenemethyl]-3H-1,3-thiazole-2-thione
CAS Number937012-09-4
PubChem CID135914553
IUPAC Name4-hydroxy-5-[(Z)-pyrrolo[2,3-b]pyridin-3-ylidenemethyl]-3H-1,3-thiazole-2-thione
Molecular FormulaC11H7N3OS2
Molecular Weight261.3
XLogP1.2
Topological Polar Surface Area115
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Heavy Atom Count17
Formal Charge0
Complexity456
SMILES
C1=CC\2=C(N=C1)N=C/C2=C\C3=C(NC(=S)S3)O
InChI
InChI=1S/C11H7N3OS2/c15-10-8(17-11(16)14-10)4-6-5-13-9-7(6)2-1-3-12-9/h1-5,15H,(H,14,16)/b6-4+
InChIKey
KWZHZGSSGANYHE-GQCTYLIASA-N
Chemical Structure
2D Structure
2D structure of 4-hydroxy-5-[(Z)-pyrrolo[2,3-b]pyridin-3-ylidenemethyl]-3H-1,3-thiazole-2-thione
CAS: 937012-09-4
CID: 135914553
Formula: C11H7N3OS2
MW: 261.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight261.3
XLogP31.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass261.00305420
Monoisotopic Mass261.00305420
Topological Polar Surface Area115 Ų
Heavy Atom Count17
Formal Charge0
Complexity456
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
T88482-01DN5355

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