(-) -Asarinin

• Description:

  (-) -Asarinin is a tetrahydrofurofurano lignan with various biological activities. (-) -Asarinin induces apoptosis in cancer cells. (-) -Asarinin promotes mitochondrial ROS accumulation, inhibits the STAT3 signaling pathway and induces apoptosis in precancerous cells. (-) -Asarinin is a Src family kinase inhibitor that suppresses mast cell activation. (-) -Asarinin is a non-competitive Δ5-desaturase inhibitor with a Ki of 0.28 mM. (-) -Asarinin possesses pain relief, anti-viral, anti-allergic and anti-tuberculous bacilli, and anti-tumor effects[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; Bacterial; Reactive Oxygen Species (ROS) ; Src; STAT; Stearoyl-CoA Desaturase (SCD)

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Infection; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/asarinin.html

• Purity:

  99.90

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  [H][C@]12[C@](CO[C@@H]2C3=CC=C(OCO4)C4=C3)([H])[C@H](C5=CC=C(OCO6)C6=C5)OC1

• Molecular Formula:

  C20H18O6

• Molecular Weight:

  354.35

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Zhao M, et al. (-) -Asarinin alleviates gastric precancerous lesions by promoting mitochondrial ROS accumulation and inhibiting the STAT3 signaling pathway. Phytomedicine. 2024 Apr;126:155348. |[2]Jeong M, et al. (-) -Asarinin from the Roots of Asarum sieboldii Induces Apoptotic Cell Death via Caspase Activation in Human Ovarian Cancer Cells. Molecules. 2018 Jul 25;23 (8) :1849. |[3]Hou Y, et al. (-) -Asarinin inhibits mast cells activation as a Src family kinase inhibitor. Int J Biochem Cell Biol. 2020 Apr;121:105701.|[4]Sakayu Shimizu, et al. Inhibition of Δ5-desaturase in polyunsaturated fatty acid biosynthesis by (−) -asarinin and (−) -epiasarinin. Phytochemistry. Volume 31, Issue 3, March 1992, Pages 757-760.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [133-04-0]