(-) -Asarinin

CAT: 0804-HY-N0701-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0701-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
(-) -Asarinin is a tetrahydrofurofurano lignan with various biological activities. (-) -Asarinin induces apoptosis in cancer cells. (-) -Asarinin promotes mitochondrial ROS accumulation, inhibits the STAT3 signaling pathway and induces apoptosis in precancerous cells. (-) -Asarinin is a Src family kinase inhibitor that suppresses mast cell activation. (-) -Asarinin is a non-competitive Δ5-desaturase inhibitor with a Ki of 0.28 mM. (-) -Asarinin possesses pain relief, anti-viral, anti-allergic and anti-tuberculous bacilli, and anti-tumor effects[1][2][3][4].
CAS Number
[133-04-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Bacterial; Reactive Oxygen Species (ROS) ; Src; STAT; Stearoyl-CoA Desaturase (SCD)
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/asarinin.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[H][C@]12[C@](CO[C@@H]2C3=CC=C(OCO4)C4=C3)([H])[C@H](C5=CC=C(OCO6)C6=C5)OC1
Molecular Formula
C20H18O6
Molecular Weight
354.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhao M, et al. (-) -Asarinin alleviates gastric precancerous lesions by promoting mitochondrial ROS accumulation and inhibiting the STAT3 signaling pathway. Phytomedicine. 2024 Apr;126:155348. |[2]Jeong M, et al. (-) -Asarinin from the Roots of Asarum sieboldii Induces Apoptotic Cell Death via Caspase Activation in Human Ovarian Cancer Cells. Molecules. 2018 Jul 25;23 (8) :1849. |[3]Hou Y, et al. (-) -Asarinin inhibits mast cells activation as a Src family kinase inhibitor. Int J Biochem Cell Biol. 2020 Apr;121:105701.|[4]Sakayu Shimizu, et al. Inhibition of Δ5-desaturase in polyunsaturated fatty acid biosynthesis by (−) -asarinin and (−) -epiasarinin. Phytochemistry. Volume 31, Issue 3, March 1992, Pages 757-760.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Alternative Products

CatalogName
AB1625Asarinin
BUP00086-01(-) -Asarinin
MBS3609413-01L-asarinin
371193Asarinin discontinued
MBS5824190DL-Asarinin
A14746-5Asarinin 5mg
A14746-25Asarinin 25mg

Popular Products