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DBeQ

CAT: 0804-HY-15945-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15945-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor, with an IC50 value of 1.5 μM and 1.6 μM for p97 (wt) and p97 (C522A), respectively; DBeQ also inhibits Vps4 with an IC50 of 11.5 μM.
CAS Number
177355-84-9
Product Name Alternative
JRF 12
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; p97
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/DBeQ.html
Purity
99.68
Solubility
DMSO : 35.71 mg/mL (ultrasonic)
Smiles
C1(NCC2=CC=CC=C2)=NC(NCC3=CC=CC=C3)=C4C=CC=CC4=N1
Molecular Formula
C22H20N4
Molecular Weight
340.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Chou TF, et al.Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc Natl Acad Sci U S A. 2011 Mar 22;108 (12) :4834-9.|[2]Zhang Y, et al. The AAA ATPase Vps4 Plays Important Roles in Candida albicans Hyphal Formation and is Inhibited by DBeQ. Mycopathologia. 2016 Jun;181 (5-6) :329-39.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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