Prochloraz

• Description :

  Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC50 of 1 μM[1][2].

• Product Name Alternative :

  BTS 40542

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H410

• Target :

  Androgen Receptor; Aryl Hydrocarbon Receptor; Estrogen Receptor/ERR; Fungal

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/prochloraz.html

• Purity :

  99.85

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=C(N1C=CN=C1)N(CCC)CCOC2=C(Cl)C=C(Cl)C=C2Cl

• Molecular Formula :

  C15H16Cl3N3O2

• Molecular Weight :

  376.67

• Precautions :

  H302, H410

• References & Citations :

  [1]E Antignac, et al. Prochloraz as potent inhibitor of benzo[a]pyrene metabolism and mutagenic activity in rat liver fractions. Toxicol Lett. 1990 Dec;54 (2-3) :309-15.|[2]Anne Marie Vinggaard, et al. Prochloraz: an imidazole fungicide with multiple mechanisms of action. Int J Androl. 2006 Feb;29 (1) :186-92.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [67747-09-5]