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Prochloraz

CAT: 0804-HY-B0845-01Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0845-01Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC50 of 1 μM[1][2].
CAS Number
67747-09-5
Product Name Alternative
BTS 40542
UNSPSC
12352005
Hazard Statement
H302, H410
Target
Androgen Receptor; Aryl Hydrocarbon Receptor; Estrogen Receptor/ERR; Fungal
Type
Reference compound
Related Pathways
Anti-infection; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Infection; Endocrinology
Assay Protocol
https://www.medchemexpress.com/prochloraz.html
Purity
99.85
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N1C=CN=C1)N(CCC)CCOC2=C(Cl)C=C(Cl)C=C2Cl
Molecular Formula
C15H16Cl3N3O2
Molecular Weight
376.67
Precautions
H302, H410
References & Citations
[1]E Antignac, et al. Prochloraz as potent inhibitor of benzo[a]pyrene metabolism and mutagenic activity in rat liver fractions. Toxicol Lett. 1990 Dec;54 (2-3) :309-15.|[2]Anne Marie Vinggaard, et al. Prochloraz: an imidazole fungicide with multiple mechanisms of action. Int J Androl. 2006 Feb;29 (1) :186-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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