N-p-trans-Coumaroyltyramine

N-p-trans-Coumaroyltyramine

• CAS Number: 36417-86-4
• UNSPSC Description: N-p-trans-Coumaroyltyramine is a cinnamoylphenethyl amide isolated from polygonum hyrcanicum, acts as an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal activity with an IC50 of 13.3 µM for T. brucei rhodesiense[1][2].
• Target Antigen: Cholinesterase (ChE); Parasite
• Type: Natural Products
• Related Pathways: Anti-infection;Neuronal Signaling
• Applications: COVID-19-immunoregulation
• Field of Research: Infection; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/n-p-trans-coumaroyltyramine.html
• Purity: 98.78
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(NCCC1=CC=C(O)C=C1)/C=C/C2=CC=C(O)C=C2
• Molecular Weight: 283.33
• References & Citations: [1]Moradi-Afrapoli F, et al. Cinnamoylphenethyl amides from Polygonum hyrcanicum possess anti-trypanosomal activity. Nat Prod Commun. 2012 Jun;7(6):753-5.|[2]Kim DK, et al. Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase. Arch Pharm Res. 2003 Sep;26(9):735-8.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported