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Chlorothalonil

CAT: 0804-HY-N6625-01Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6625-01Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Chlorothalonil is a broad-spectrum foliar fungicide with oral activity. Chlorothalonil can be used to combat fungal diseases in vegetable and crop leaves. Chlorothalonil can alter the microbial community in the soil. Chlorothalonil inhibits spermatogenesis. Chlorothalonil can cause intestinal epithelial barrier dysfunction and fetal toxicity[1][2][3][4][5].
CAS Number
1897-45-6
UNSPSC
12352005
Hazard Statement
H317, H318, H330, H335, H351, H410
Target
Estrogen Receptor/ERR; Fungal
Type
Reference compound
Related Pathways
Anti-infection; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/chlorothalonil.html
Concentration
10mM
Purity
98.15
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
N#CC1=C(Cl)C(Cl)=C(Cl)C(C#N)=C1Cl
Molecular Formula
C8Cl4N2
Molecular Weight
265.91
Precautions
H317, H318, H330, H335, H351, H410
References & Citations
[1]Farag A T, et al. Embryotoxicity of oral administered chlorothalonil in mice[J]. Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2006, 77 (2) : 104-109.|[2]Sigler W V, et al. The impact of chlorothalonil application on soil bacterial and fungal populations as assessed by denaturing gradient gel electrophoresis[J]. Applied Soil Ecology, 2002, 21 (2) : 107-118.|[3]Singh BK, et al. Degradation of chlorpyrifos, fenamiphos, and chlorothalonil alone and in combination and their effects on soil microbial activity. Environ Toxicol Chem. 2002 Dec;21 (12) :2600-5. PMID: 12463554.|[4]Tao H, et al. Chlorothalonil induces the intestinal epithelial barrier dysfunction in Caco-2 cell-based in vitro monolayer model by activating MAPK pathway. Acta Biochim Biophys Sin (Shanghai) . 2021 Nov 10;53 (11) :1459-1468. |[5]Zhang P, et al. Low dose chlorothalonil impairs mouse spermatogenesis through the intertwining of Estrogen Receptor Pathways with histone and DNA methylation. Chemosphere. 2019 Sep;230:384-395.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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