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Clitocine

CAT: 0804-HY-118341-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118341-01Size:1 mg
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Description
Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity[1][2].
CAS Number
105798-74-1
Product Name Alternative
CA-074Me, T-Type calcium channel inhibitor
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/clitocine.html
Purity
95.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](NC2=C([N+]([O-])=O)C(N)=NC=N2)O1
Molecular Formula
C9H13N5O6
Molecular Weight
287.23
References & Citations
[1]Friesen WJ, et al. The nucleoside analog clitocine is a potent and efficacious readthrough agent. RNA. 2017;23 (4) :567-577.|[2]Sun JG, et al. Clitocine potentiates TRAIL-mediated apoptosis in human colon cancer cells by promoting Mcl-1 degradation. Apoptosis. 2016;21 (10) :1144-1157.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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