(-) -Alkannin

• Description:

  (-) -Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-) -Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-) -Alkannin improves hepatic inflammation in a Rho-kinase pathway[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis

• Type:

  Natural Products

• Related Pathways:

  Apoptosis

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/alkannin.html

• Concentration:

  10mM

• Purity:

  99.88

• Solubility:

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles:

  OC1=C2C(C(C=C([C@H](C/C=C(C)/C)O)C2=O)=O)=C(O)C=C1

• Molecular Formula:

  C16H16O5

• Molecular Weight:

  288.30

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Hosokawa Y, et al. Alkannin inhibits CCL3 and CCL5 production in human periodontal ligament cells. Cell Biol Int. 2016 Dec;40 (12) :1380-1385.|[2]Huu Tung N, et al. Naphthoquinone components from Alkanna tinctoria (L.) Tausch show significant antiproliferative effects on human colorectal cancer cells. Phytother Res. 2013 Jan;27 (1) :66-70.|[3]Xue W, et al. Alkannin Inhibited Hepatic Inflammation in Diabetic Db/Db Mice. Cell Physiol Biochem. 2018;45 (6) :2461-2470.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [517-88-4]