STAT3-IN-15

STAT3-IN-15

• UNSPSC Description: STAT3-IN-15 is a potent and orally active STAT3 inhibitor against idiopathic pulmonary fibrosis (IPF). STAT3-IN-15 inhibits STAT3 phosphorylation. STAT3-IN-15 also inhibits the migration and deformation of epithelial cells induced by TGF-β1 and inhibit epithelial-mesenchymal transition (EMT)[1].
• Target Antigen: STAT
• Type: Reference compound
• Related Pathways: JAK/STAT Signaling;Stem Cell/Wnt
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/stat3-in-15.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(N1CCN(CC1)CC2=CC(F)=C(C=C2F)F)C3=CC4=CC=CC=C4S3(=O)=O
• Molecular Weight: 422.42
• References & Citations: [1]Wang Y, et al. Discovery of the novel Benzo[b]thiophene 1,1-dioxide derivatives as a potent STAT3 inhibitor against idiopathic pulmonary fibrosis. Eur J Med Chem. 2022 Nov 28;246:114953.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported