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Biacetyl monoxime

CAT: 0804-HY-Y0413-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-Y0413-01Size:100 mg
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Description
Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II. Biacetyl monoxime induces sarcoplasmic reticulum Ca2+ release[1][2][3].
CAS Number
57-71-6
Product Name Alternative
Diacetyl monoxime; DAM
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Myosin; Na+/K+ ATPase
Type
Reference compound
Related Pathways
Cytoskeleton; Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/biacetyl-monoxime.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C/C(C(C)=O)=N\O
Molecular Formula
C4H7NO2
Molecular Weight
101.10
Precautions
H302, H315, H319, H335
References & Citations
[1]Kohsuke Hashimoto, et al. The myosin ATPase inhibitor, 2,3-butanedione 2-monoxime, prevents protein secretion by the basidiomycete Coprinopsis cinerea. Biotechnol Lett. 2011 Apr;33 (4) :769-75.|[2]R M Phillips, et al. 2,3-Butanedione 2-monoxime (BDM) induces calcium release from canine cardiac sarcoplasmic reticulum. Biochem Biophys Res Commun. 1996 Dec 4;229 (1) :154-7. |[3]Ostap EM. 2,3-Butanedione monoxime (BDM) as a myosin inhibitor. J Muscle Res Cell Motil. 2002;23 (4) :305-8.|[4]Xiao YF, et al. Effects of 2,3-butanedione monoxime on blood pressure, myocardial Ca2+ currents, and action potentials of rats. Am J Hypertens. 1995 Dec;8 (12 Pt 1) :1232-40.|[5]Brightman T, et al. 2,3-Butanedione monoxime protects mice against the convulsant effect of picrotoxin by facilitating GABA-activated currents. Brain Res. 1995 Apr 24;678 (1-2) :110-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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