Mebendazole

CAT: 0804-HY-17595-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-17595-01Size:500 mg
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Description
Mebendazole is a highly effective, broad-spectrum antihelmintic against nematode infestations. Mebendazole also exhibits inhibitory effect against glioblastoma multiforme (GBM), inhibits Hedgehog pathway and tubulin polymerization. Mebendazole is orally active and can cross CNS penetration[1][2][3].
CAS Number
[31431-39-7]
UNSPSC
12352005
Hazard Statement
H302, H350, H360
Target
Apoptosis; Microtubule/Tubulin; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Mebendazole.html
Purity
99.88
Solubility
DMSO : 4.17 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
O=C(OC)NC1=NC2=CC=C(C(C3=CC=CC=C3)=O)C=C2N1
Molecular Formula
C16H13N3O3
Molecular Weight
295.29
Precautions
H302, H350, H360
References & Citations
[1]Bai RY, et al. Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. Neuro Oncol. 2011 Sep;13 (9) :974-82. |[2]Larsen AR, et al. Repurposing the antihelmintic mebendazole as a hedgehog inhibitor. Mol Cancer Ther. 2015 Jan;14 (1) :3-13. |[3]Erdinçler P, et al. The role of mebendazole in the surgical treatment of central nervous system hydatid disease. Br J Neurosurg. 1997 Apr;11 (2) :116-20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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