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AS19

CAT: 0804-HY-103142-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103142-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AS19 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively) . AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia[1][2][3].
CAS Number
1000578-26-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/as19.html
Purity
99.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(C2=CC=CC3=C2CC[C@H](N(C)C)C3)C(C)=NN1C
Molecular Formula
C18H25N3
Molecular Weight
283.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Perez-García GS, et al. Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task. Behav Brain Res. 2005 Aug 30;163 (1) :136-40.|[2]León-Ponte M, et al. Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor. Blood. 2007 Apr 15;109 (8) :3139-46.|[3]Brenchat A, et al. 5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice. Pain. 2009 Feb;141 (3) :239-47.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT5 Receptor;5-HT7 Receptor; mLAG-3; MUC3; Prostaglandin D Synthase

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CatalogName
T10380-01AS19

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