Luotonin F

• UNSPSC Description:

  Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II[1][2].

• Target Antigen:

  Topoisomerase

• Type:

  Natural Products

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/luotonin-f.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1NC(C(C2=CC3=C(N=C2)C=CC=C3)=O)=NC4=CC=CC=C41

• Molecular Weight:

  301.30

• References & Citations:

  [1]Liang JL, et al. Recent advances in the studies on luotonins. Molecules. 2011 Jun 14;16(6):4861-83.|[2]Ma Z, et al. Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1193-6.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  244616-85-1