Luotonin F

• Description :

  Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II[1][2].

• CAS Number :

  [244616-85-1]

• UNSPSC :

  12352005

• Target :

  Topoisomerase

• Type :

  Natural Products

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/luotonin-f.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1NC(C(C2=CC3=C(N=C2)C=CC=C3)=O)=NC4=CC=CC=C41

• Molecular Formula :

  C18H11N3O2

• Molecular Weight :

  301.30

• References & Citations :

  [1]Liang JL, et al. Recent advances in the studies on luotonins. Molecules. 2011 Jun 14;16 (6) :4861-83.|[2]Ma Z, et al. Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities. Bioorg Med Chem Lett. 2004 Mar 8;14 (5) :1193-6.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Topo II