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Adavivint

CAT: 0804-HY-109049-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109049-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Adavivint (SM04690; Lorecivivint) is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells[1].
CAS Number
1467093-03-3
Product Name Alternative
SM04690; Lorecivivint
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Wnt
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/Adavivint.html
Purity
98.85
Solubility
DMSO : 25 mg/mL (ultrasonic; warming) |H2O : < 0.1 mg/mL
Smiles
CC(C)CC(NC1=CC(C2=CC3=C(NN=C3C(N4)=NC5=C4C(C6=CC=CC(F)=C6)=CN=C5)C=C2)=CN=C1)=O
Molecular Formula
C29H24FN7O
Molecular Weight
505.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Deshmukh V, et al. A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee. Osteoarthritis Cartilage. 2018 Jan;26 (1) :18-27.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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