Berninamycin A

• Description:

  Berninamycin A is a cyclic thiopeptide antibiotic first isolated from S. bernensis. It inhibits protein biosynthesis in Gram positive bacteria through binding with ribosomal subunits. Cyclic thiopeptide antibiotics, including berninamycin A, induce the transcriptional activator TipA in Streptomyces.

• UNSPSC:

  12352209

• Target:

  Antibiotic; Bacterial

• Type:

  Peptides

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/berninamycin-a.html

• Smiles:

  O=C(C1=NC(C2=COC3=N2)=C(C4=NC(C(N[C@]([C@H](O)C)([H])C(N/C(C5=NC(C(NC(C(N[C@@H](C(C)(O)C)C(NC(C6=NC(C(NC(C(NC3=C)=O)=C)=O)=C(C)O6)=C)=O)=O)=C)=O)=C(C)O5)=C\C)=O)=O)=CS4)C=C1)NC(C(NC(C(N)=O)=C)=O)=C

• Molecular Formula:

  C51H51N15O15S

• Molecular Weight:

  1146.11

• References & Citations:

  [1]Chiu, et al. Broad spectrum thiopeptide recognition specificity of the Streptomyces lividans TipAL protein and its role in regulating gene expression. J. Biol. Chem. 274 (29), 20578-20586 (1999) .

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [58798-97-3]