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DS55980254

CAT: 0804-HY-158145-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-158145-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DS55980254 is the orally active inhibitor for phosphatidylserine synthase 1 (PTDSS1) that blocks the synthesis of intracellular phosphatidylserine. PTDSS1 deficiency affects the balance of cell membrane phospholipid components, and activates B cell receptor (BCR) signaling pathway[1][2].
CAS Number
2488609-43-2
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ds55980254.html
Purity
99.65
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
FC(C)(CN1[C@](C2=CC=C(OC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C=C2)([H])C4=C(C5=CC=CC(N6)=C5OC6=O)NN=C4C1=O)F
Molecular Formula
C29H18F8N4O4
Molecular Weight
638.46
References & Citations
[1]Keisuke Suzuki, et al. Efficient Multikilogram-Scale Synthesis of PTDSS1 Inhibitor: Development of a Practical and Scalable Optical Resolution Method for Chiral 2,3-Pyrrolidinedione. Org. Process Res. Dev. 2024.|[2]Omi J, et al., Phosphatidylserine synthesis controls oncogenic B cell receptor signaling in B cell lymphoma. J Cell Biol. 2024 Feb 5;223 (2) :e202212074.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19231905DS55980254

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