Fmoc-His(Trt)-OH-15N3

Fmoc-His(Trt)-OH-15N3

• CAS Number: 1217696-12-2
• UNSPSC Description: Fmoc-His(Trt)-OH-15N3 is the 15N labeled Fmoc-His(Trt)-OH[1]. Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[2].
• Target Antigen: Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Others
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/fmoc-his-trt-oh-15n3.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(O)[C@H](CC1=C[15N](C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C=[15N]1)[15NH]C(OCC5C6=C(C7=C5C=CC=C7)C=CC=C6)=O
• Molecular Weight: 622.69
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Yi Y, et, al. Suppression of Simultaneous Fmoc-His(Trt)-OH Racemization and Nα-DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid Activation Strategy in Peptide Synthesis. Org. Process Res. Dev. 2022 Jun 27.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported