Orteronel

CAT: 0804-HY-10505-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10505-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Orteronel (TAK-700) is a highly selective inhibitor of human 17,20-lyase (CYP17) with IC50 of 38 nM, and exhibits >1000-fold selectivity over other CYPs such as 11-hydroxylase and CYP3A4[1][2].
CAS Number
[566939-85-3]
Product Name Alternative
TAK-700
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Orteronel.html
Concentration
10mM
Purity
99.90
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C2C=C([C@@]3(O)CCN4C=NC=C43)C=CC2=C1)NC
Molecular Formula
C18H17N3O2
Molecular Weight
307.35
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Yamaoka M, et al. Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys. J Steroid Biochem Mol Biol. 2012 Apr;129 (3-5) :115-28.|[2]Kaku, Tomohiro., et al. Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer. From Bioorganic & Medicinal Chemistry (2011), 19 (21), 6
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
CYP17

Related Products

CatalogName

Alternative Products

CatalogName
A3686-10Orteronel
206784Orteronel (racemic)
MBS386258-01TAK-700 (Orteronel)
A22508-1Orteronel (racemic) 1mg
A22508-100Orteronel (racemic) 100mg
MBS3607502-01(S/R)-Orteronel
A22508-50Orteronel (racemic) 50mg
A22508-10Orteronel (racemic) 10mg
A22508-200Orteronel (racemic) 200mg
M17508-01(S/R) -Orteronel

Popular Products