Naphthol AS-E

• Description :

  Naphthol AS-E is a potent and cell-permeable inhibitor of KIX-KID interaction. Naphthol AS-E directly binds to the KIX domain of CBP (Kd:8.6 μM), blocks the interaction between the KIX domain and the KID domain of CREB with IC50 of 2.26 μM. Naphthol AS-E can be used for cancer research.

• CAS Number :

  [92-78-4]

• UNSPSC :

  12352005

• Hazard Statement :

  H317, H319

• Target :

  Epigenetic Reader Domain; Histone Acetyltransferase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/naphthol-as-e.html

• Concentration :

  10mM

• Purity :

  98.0

• Solubility :

  DMSO : 41.67 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C(O)C=C2C=CC=CC2=C1)NC3=CC=C(Cl)C=C3

• Molecular Formula :

  C17H12ClNO2

• Molecular Weight :

  297.74

• Precautions :

  H317, H319

• References & Citations :

  [1]Fuchun Xie, et al. Synthesis and Evaluation of an O-Aminated Naphthol AS-E as a Prodrug of CREB-mediated Gene Transcription Inhibition. Lett Org Chem. 2013 Jun;10 (5) :380-384.|[2]Bingbing X Li, et al. Discovery of a small-molecule inhibitor of the KIX-KID interaction. Chembiochem. 2009 Nov 23;10 (17) :2721-4.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CBP/p300