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VU0238441

CAT: 0804-HY-12158-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12158-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively[1][2].
CAS Number
85511-68-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0238441.html
Purity
99.87
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1N(CC2=CC=C(C(F)(F)F)C=C2)C3=C(C=CC=C3Cl)C1=O
Molecular Formula
C16H9ClF3NO2
Molecular Weight
339.70
Precautions
H302, H315, H319, H335
References & Citations
[1]Thomas M Bridges, et al. Chemical lead optimization of a pan G (q) mAChR M (1), M (3), M (5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M (5) PAM. Bioorg Med Chem Lett. 2010 Jan 15;20 (2) :558-62.|[2]Thomas M Bridges, et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem. 2009 Jun 11;52 (11) :3445-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR1; mAChR2; mAChR3; mAChR4; mAChR5

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