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Syringaresinol

CAT: 0804-HY-N8307-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N8307-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Syringaresinol is a lignan-type phytochemical with anti-inflammatory activities. Syringaresinol inhibits the NF-κB and AKT signaling pathway in IL-1β-activated mouse chondrocytes. Syringaresinol increases phosphorylation of AMPK, eNOS, and intracellular Ca2+ levels in HUVECs. Syringaresinol attenuates osteoarthritis progression in mice with Destabilization of the Medial Meniscus (DMM) -induced osteoarthritis. Syringaresinol can be used for the study of osteoarthritis (OA) [1][2].
CAS Number
487-35-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Akt; AMPK; Calcium Channel; NF-κB; NO Synthase
Type
Natural Products
Related Pathways
Epigenetics; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/syringaresinol.html
Purity
99.66
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=C(OC)C=C(C2OCC3C2COC3C4=CC(OC)=C(O)C(OC)=C4)C=C1OC
Molecular Formula
C22H26O8
Molecular Weight
418.44
Precautions
H302, H315, H319
References & Citations
[1]Chung BH, et al. Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase. Exp Mol Med. 2012 Mar 31;44 (3) :191-201. |[2]Wang X, et al. Syringaresinol attenuates osteoarthritis via regulating the NF-κB pathway. Int Immunopharmacol. 2023 May;118:109982.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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