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AR7

CAT: 0804-HY-101106-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-101106-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy[1].
CAS Number
80306-38-3
UNSPSC
12352005
Hazard Statement
H410
Target
RAR/RXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/AR7.html
Concentration
10mM
Purity
99.38
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1
Molecular Formula
C15H12ClNO
Molecular Weight
257.71
Precautions
H410
References & Citations
[1]Anguiano J, et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat Chem Biol. 2013 Jun;9 (6) :374-82.|[2]Philip Wing-Lok Ho, et al. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA) . Autophagy. 2020 Feb;16 (2) :347-370.|[3]Mathieu Bourdenx, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021 May 13;184 (10) :2696-2714.e25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

7-Chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine
CAS Number80306-38-3
PubChem CID44250175
IUPAC Name7-chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine
Molecular FormulaC15H12ClNO
Molecular Weight257.71
XLogP4.1
Topological Polar Surface Area21.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count18
Formal Charge0
Complexity322
SMILES
CC1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)Cl)OC2
InChI
InChI=1S/C15H12ClNO/c1-10-2-4-11(5-3-10)14-9-18-15-8-12(16)6-7-13(15)17-14/h2-8H,9H2,1H3
InChIKey
MVOZLTFXYGHZPM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 7-Chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine
CAS: 80306-38-3
CID: 44250175
Formula: C15H12ClNO
MW: 257.71
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight257.71
XLogP34.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass257.0607417
Monoisotopic Mass257.0607417
Topological Polar Surface Area21.6 Ų
Heavy Atom Count18
Formal Charge0
Complexity322
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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