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L-685458

CAT: 0804-HY-19369-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19369-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-685458 is a potent transition state analog (TSA) γ-secretase inhibitor (GSI) . L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimer’s disease (AD) and cancers[1][2].
CAS Number
292632-98-5
Product Name Alternative
L-685,458
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; γ-secretase
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/L-685458.html
Purity
99.48
Solubility
DMSO : 83.3 mg/mL (ultrasonic; warming)
Smiles
O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)C[C@@H](O)[C@@H](NC(OC(C)(C)C)=O)CC3=CC=CC=C3)=O)=O
Molecular Formula
C39H52N4O6
Molecular Weight
672.85
Precautions
H302, H315, H319, H335
References & Citations
[1]Shearman, M.S., Beher, D., Clarke, E.E., Lewis, H.D., Harrison, T., Hunt, P., |[2]Guanghui Yang, et al. Structural basis of γ-secretase inhibition and modulation by small molecule drugs. Cell. 2021 Jan 21;184 (2) :521-533.e14.|[3]Jonas Sjölund, et al. Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo. J Clin Invest. 2008 Jan;118 (1) :217-28.|[4]Kazunori Kawaguchi, et al. Jagged1 DNA Copy Number Variation Is Associated with Poor Outcome in Liver Cancer. Am J Pathol. 2016 Aug;186 (8) :2055-2067.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
T6870-01L-685458
MBS131513-01L-685458 (L-685,458; L685458; L 685458)
A15899-2L-685458 2mg
A15899-50L-685458 50mg
A15899-25L-685458 25mg
A15899-10L-685458 10mg
A15899-100L-685458 100mg
A15899-5L-685458 5mg
A15899-1L-685458 1mg
A15899-10mM-DL-685458 10mM * 1mL in DMSO

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