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Dinotefuran

CAT: 0804-HY-B0827-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0827-01Size:50 mg
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Description
Dinotefuran is an orally active and competitive inhibitor and insecticide targeting insect nicotinic acetylcholine receptors (nAChRs) . Dinotefuran blocks neural signaling and induces neural dysfunction in insects. Dinotefuran binds to [3H]epibatidine in the neural cord membrane of American cockroach with an IC50 of 890 nM and to [3H]α-bungarotoxin with an IC50 of 36.1 μM. Dinotefuran exhibits knockdown activity (KD50=0.351 nmol/g) and lethal activity (LD50=0.173 nmol/g) against German cockroach. Dinotefuran is mainly used for agricultural pest control, such as field control of piercing-sucking and chewing insects (e.g., aphids, planthoppers), while its environmental toxicological effects (e.g., oxidative stress and reproductive neurotoxicity on earthworms) are also a research focus to assess ecological risks[1][2][3].
CAS Number
165252-70-0
Product Name Alternative
MTI-446
UNSPSC
12352005
Hazard Statement
H332, H410
Target
NAChR; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Dinotefuran.html
Concentration
10mM
Purity
99.74
Solubility
DMSO : 66.67 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
O=[N+](N/C(NC)=N/CC1COCC1)[O-]
Molecular Formula
C7H14N4O3
Molecular Weight
202.21
Precautions
H332, H410
References & Citations
[1]Mori K, et al. Interaction of dinotefuran and its analogues with nicotinic acetylcholine receptors of cockroach nerve cords. Pest Manag Sci. 2002 Feb;58 (2) :190-6.|[2]Liu T, et al. Biochemical and genetic toxicity of dinotefuran on earthworms (Eisenia fetida) . Chemosphere. 2017 Jun;176:156-164.|[3]Tanaka T, et al. Reproductive and neurobehavioral effects of dinotefuran in an F1 -generation toxicity study in mice. Birth Defects Res. 2023 Oct 1;115 (16) :1534-1555.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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