Tpl2 Kinase Inhibitor 1

Tpl2 Kinase Inhibitor 1

• CAS Number: 871307-18-5
• UNSPSC Description: Tpl2 Kinase Inhibitor 1 is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC50=50 nM). Tpl2 consists of COT kinase and MAP3K8. Tpl2 Kinase Inhibitor 1 plays an important role in the regulation of the inflammatory response and the progression of some cancers[1][2].
• Target Antigen: MAP3K; MAPKAPK2 (MK2); p38 MAPK
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/tpl2-kinase-inhibitor-1.html
• Purity: 99.22
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: N#CC1=C(NC2=CC=C(F)C(Cl)=C2)C3=CC(NCC4=CC=CN=C4)=NC=C3N=C1
• Molecular Weight: 404.83
• References & Citations: [1]Glatthar R, et al. Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J Med Chem. 2016 Aug 25;59(16):7544-60.|[2]Gavrin LK, et al. Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5288-92.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported