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Methyl syringate

CAT: 0804-HY-W002116-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W002116-01Size:500 mg
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Description
Methyl syringate is a selective TRPA1 agonist. Methyl syringate regulates food intake and gastric emptying through a TRPA1-mediated pathway. Methyl syringate is an efficient phenolic mediator for bacterial and fungal laccases. Methyl syringate is a chemical marker of Asphodel monofloral honey. Methyl syringate contributes to the antibacterial activity of honey. Methyl syringate inhibits aflatoxin production. Methyl syringate can contribute to weight suppression. Methyl syringate can be studies for cancer prevention (e.g. lung cancer), suppression of hypoxia-induced inflammatory response and tumorigenesis[1][2][3][4].
CAS Number
884-35-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; COX; Phosphatase; TRP Channel
Type
Natural Products
Related Pathways
Anti-infection; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/methyl-syringate.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(OC)C1=CC(OC)=C(O)C(OC)=C1
Molecular Formula
C10H12O5
Molecular Weight
212.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Tuberoso CI, et al. Methyl syringate: a chemical marker of asphodel (Asphodelus microcarpus Salzm. et Viv.) monofloral honey. J Agric Food Chem. 2009 May 13;57 (9) :3895-900.|[2]Rosado T, et al. Methyl syringate: an efficient phenolic mediator for bacterial and fungal laccases. Bioresour Technol. 2012 Nov;124:371-8.|[3]Kim MJ, et al. The TRPA1 agonist, methyl syringate suppresses food intake and gastric emptying. PLoS One. 2013 Aug 21;8 (8) :e71603.|[4]Joonwoo Park, et al., Methyl syringate, a TRPA1 agonist represses hypoxia-induced cyclooxygenase-2 in lung cancer cells, Phytomedicine, Volume 23, Issue 3, 2016, Pages 324-329, ISSN 0944-7113.|[5]Ahn D, et al., Methyl Syringate Stimulates Glucose Uptake by Inhibiting Protein Tyrosine Phosphatases Relevant to Insulin Resistance. Life. 2023; 13 (6) :1372.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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