Diazinon

• Description :

  Diazinon is an orally active, irreversible AChE inhibitor and insecticide that can be absorbed through the digestive system, skin or respiratory tract. Diazinon inhibits AChE, leading to accumulation of acetylcholine, which in turn overstimulates ACh receptors and affects the nervous system. Diazinon also produces reactive oxygen species (ROS), which induce oxidative stress in various tissues. Diazinon is mainly used in the agricultural field as an insecticide and may have potential effects on human and animal health[1][2][3][4].

• Product Name Alternative :

  Dimpylate

• UNSPSC :

  12352005

• Hazard Statement :

  H301-H350-H410

• Target :

  Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/Diazinon.html

• Purity :

  99.71

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  S=P(OCC)(OCC)OC1=NC(C(C)C)=NC(C)=C1

• Molecular Formula :

  C12H21N2O3PS

• Molecular Weight :

  304.35

• Precautions :

  P264-P270-P273-P280-P330-P391-P405-P501

• References & Citations :

  [1]Girón-Pérez MI, et al. Diazinon toxicity in hepatic and spleen mononuclear cells is associated to early induction of oxidative stress. Int J Environ Health Res. 2022 Oct;32 (10) :2309-2323.|[2]Zein MA, et al. Toxic effects of combined stressors on Daphnia pulex: Interactions between diazinon, 4-nonylphenol, and wastewater effluent. Environ Toxicol Chem. 2015 May;34 (5) :1145-53.|[3]Shah MD, et al. Diazinon-induced oxidative stress and renal dysfunction in rats. Food Chem Toxicol. 2010 Dec;48 (12) :3345-53.|[4]Neishabouri EZ, et al. Evaluation of immunotoxicity induced by diazinon in C57bl/6 mice. Toxicology. 2004 Mar 15;196 (3) :173-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [333-41-5]