Domperidone

• Description :

  Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1].

• CAS Number :

  [57808-66-9]

• Product Name Alternative :

  R33812

• UNSPSC :

  12352005

• Hazard Statement :

  H361

• Target :

  Dopamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/domperidone.html

• Concentration :

  10mM

• Purity :

  99.87

• Solubility :

  DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic)

• Smiles :

  O=C1NC2=CC(Cl)=CC=C2N1C3CCN(CCCN4C5=CC=CC=C5NC4=O)CC3

• Molecular Formula :

  C22H24ClN5O2

• Molecular Weight :

  425.91

• Precautions :

  H361

• References & Citations :

  [1]Reddymasu SC, et al. Domperidone: review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol. 2007;102 (9) :2036-2045.|[2]Champion MC, et al. Domperidone, a new dopamine antagonist. CMAJ. 1986;135 (5) :457-461.|[3]Stoetzer C, et al. Cardiotoxic Antiemetics Metoclopramide and Domperidone Block Cardiac Voltage-Gated Na+ Channels. Anesth Analg. 2017 Jan. 124 (1) :52-60.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  D2 Receptor