Clopidogrel thiolactone

• Description:

  Clopidogrel thiolactone is an important intermediate in the metabolism of Clopidogrel (HY-15283) . Clopidogrel thiolactone has antiplatelet aggregatione effects. Clopidogrel is a P2Y12 receptor inhibitor that exerts antiplatelet effects[1][2].

• UNSPSC:

  12352005

• Target:

  Drug Metabolite; P2Y Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Clopidogrel-thiolactone.html

• Concentration:

  10mM

• Purity:

  98.0

• Solubility:

  DMSO : 50 mg/mL (ultrasonic) |Ethanol : 5 mg/mL (ultrasonic; warming; heat to 40°C)

• Smiles:

  O=C(OC)[C@@H](N1CCC(S2)C(C1)=CC2=O)C3=C(Cl)C=CC=C3

• Molecular Formula:

  C16H16ClNO3S

• Molecular Weight:

  337.82

• References & Citations:

  [1]Shan J, et, al. Overcoming clopidogrel resistance: discovery of vicagrel as a highly potent and orally bioavailable antiplatelet agent. J Med Chem. 2012 Apr 12;55 (7) :3342-52.|[2]Hagihara K, et, al. Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs. Xenobiotica. 2009 Mar;39 (3) :218-26.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  P2Y12 Receptor

• CAS Number:

  [1147350-75-1]