Imazalil

• Description:

  Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder[1][2][3].

• Product Name Alternative:

  Enilconazole

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H318, H332, H410

• Target:

  Fungal; Pregnane X Receptor (PXR)

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/Imazalil.html

• Purity:

  99.54

• Solubility:

  DMSO : ≥ 100 mg/mL|H2O : 20 mg/mL (ultrasonic)

• Smiles:

  C=CCOC(C1=CC=C(Cl)C=C1Cl)CN2C=CN=C2

• Molecular Formula:

  C14H14Cl2N2O

• Molecular Weight:

  297.18

• Precautions:

  H301, H318, H332, H410

• References & Citations:

  [1]Hiroyuki Kojima, et al. Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ. Toxicol Appl Pharmacol. 2012 Mar 15;259 (3) :338-45.|[2]Shohei Yoshimaru, et al. Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR. J Toxicol Sci. 2018;43 (7) :443-450.|[3]Cuiyuan Jin, et al. Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels. Environ Toxicol. 2018 Jun;33 (6) :650-658.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [35554-44-0]