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Imazalil

CAT: 0804-HY-B1134-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1134-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder[1][2][3].
CAS Number
35554-44-0
Product Name Alternative
Enilconazole
UNSPSC
12352005
Hazard Statement
H301, H318, H332, H410
Target
Fungal; Pregnane X Receptor (PXR)
Type
Natural Products
Related Pathways
Anti-infection; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Imazalil.html
Purity
99.54
Solubility
DMSO : ≥ 100 mg/mL|H2O : 20 mg/mL (ultrasonic)
Smiles
C=CCOC(C1=CC=C(Cl)C=C1Cl)CN2C=CN=C2
Molecular Formula
C14H14Cl2N2O
Molecular Weight
297.18
Precautions
H301, H318, H332, H410
References & Citations
[1]Hiroyuki Kojima, et al. Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ. Toxicol Appl Pharmacol. 2012 Mar 15;259 (3) :338-45.|[2]Shohei Yoshimaru, et al. Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR. J Toxicol Sci. 2018;43 (7) :443-450.|[3]Cuiyuan Jin, et al. Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels. Environ Toxicol. 2018 Jun;33 (6) :650-658.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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